Scientific Testing and Kolorex Horopito Product News

Kolorex products are informed by years of science.

Horopito & Polygodial – Proven Anti-Candida Herb

In 1982 researchers at Canterbury University published compelling results showing the extraordinary antifungal activity of Horopito extracts against the yeast-like fungus Candida albicans. This activity is due to the main active ingredient, polygodial.

Since the identification of polygodial in horopito, there have been numerous scientific papers published confirming both in vitro and in vivo this unique and effective antifungal activity.  Download our Scientific Summary to find out more.

The graph below shows the research from scientists at the University of Canterbury showing an extract from New Zealand’s Horopito plant containing polygodial was more effective at killing Candida albicans than the powerful pharmaceutical anti-Candida drug, Amphotericin B.

The graph shows polygodial has a larger zone inhibiting the growth of Candida albicans and the zone is formed within 1 day. This means that polygodial has stronger and faster antifungal action than Amphotericin B.
(Reference: McCallion et al 1982. Planta Medica, vol 44, pp134-138)

Three years later Forest Herbs Research began developing ways to offer this ancient herb’s candida killing benefits to you in Kolorex’s Horopito-based range of natural health products.

Traditional Usage – A History of Safe Remedial Use

Plants containing polygodial have been used traditionally as foods and medicines in NZ, Japan, South America and Africa. This traditional use supports its safe use. Polygodial and Horopito have also undergone scientific tests to ensure that they are safe for human use (both external and internal).  The Maori people of New Zealand had known of the strength of this ancient plant for centuries – it was one of their traditional herbal remedies.  Maori would chew the leaves and spit the juice on to skin complaints.  And it was also used by the early European settlers.  They would boil Horopito leaves and drink the resulting tea as a cure for stomach ache.

Ongoing Scientific Testing – Monitoring Efficacy

Horopito leaf, horopito extract and Kolorex products are scientifically tested by Cawthron Institute and Southern Cross Plant Science to check antifungal efficacy against Candida albicans and to assay the polygodial content.
Each batch of  Kolorex softgels undergoes a challenge test for efficacy. In the laboratory the sample is inoculated with approximately one million live colonies of Candida albicans. The number of colonies are monitored and measured after 3 and 7 days to ensure the efficacy of the product.
Each supercritical CO2 oleoresin extract of Horopito used in Kolorex creams and softgels is analysed to determine the polygodial content. Polygodial is the compound which ensures antifungal activity against Candida albicans and gives Kolorex creams their heat and softgels their peppery pungent taste. The hotter they are the stronger the antifungal power.

Sustainable Farming of Kolorex Horopito

Building on traditional usage and the University of Canterbury discovery, Forest Herbs Research sampled  wild-growing Horopito.  They discovered a 5 times variation between populations in effectiveness against Candida albicans.  Forest Herbs Research then spent years learning how to domesticate and sustainably harvest these slow growing shrubs, eventually planting two farms in the variety that is most powerful against Candida albicans.  These are known as Kolorex Horopito.

Horopito leaves contain such good defences against fungi and predators the plant has been able to survive largely unchanged for 65 million years.  It is one of the world’s oldest flowering plants. However its age means it has a very primitive vascular (water transporting) system so it dies quickly if the ground is dry.  Forest Herb’s solution was to site both its farms next to the temperate rainforests of the Kahurangi National Park.